Notre Dame maintains rivalries with many programs in the Big Ten, but USC undoubtedly is near the top of the list. No annual series matches programs with more national titles. Notre Dame beat USC 49-35 at Los Angeles Memorial Coliseum in 2024. It leads the all-time series 50-37-5.

The contract between USC and Notre Dame is set to expire and one of football’s most storied rivalries in danger of ending.