After missing last week because of a hamstring injury, San Francisco 49ers running back Isaac Guerendo is set to play Monday night against the Detroit Lions. Guerendo, who has been listed as limited in practice this week with foot and hamstring issues,

The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a hamstring injury, does not have

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.