Clooney and Wyle, who played Doug Ross and John Carter, respectively, starred alongside each other on the hit medical drama for five seasons before Clooney exited the series to focus on other acting endeavors. Wyle continued with the show through season 11, making guest appearances in seasons 12 and 15. ER ran from 1994 to 2009.

George Clooney appeared on 'The Late Show With Seth Meyers' and praised Noah Wyle for his new show, 'The Pitt,' and admitted he was jealous he could memorize all the medical jargon on 'E.R'