Results Eight RCTs (n = 3,791) were reviewed. Significantly greater ACR20 response rates were observed in patients receiving tofacitinib 5 and 10 mg bid (twice daily) versus placebo at week 12 ...

Tofacitinib generally raises LDL levels, more than occurs with TNF blockers, but the increase was lower with statin use. LDL levels on treatment in the 5-mg tofacitinib group were nearly the same ...

6 mg or 12 mg once per day, tofacitinib (Xeljanz, Pfizer) 5 mg twice per day and upadacitinib (Rinvoq, Abbvie) 15 mg daily. The meta-analysis ultimately included nine randomized controlled trials ...