Context Enhanced platelet inhibition by clopidogrel decreases the risk of ischemic events but carries a risk for a concomitant increase in bleeding. Objectives To compare the efficacy and safety of ...

Abstract A series of optically active 2-hydroxytetrahydrothienopyridine derivatives were designed and synthesized as prodrugs of clopidogrel thiolactone in order to overcome clopidogrel resistance.

In patients who received omeprazole in addition to aspirin and clopidogrel, the mean PRI at day 7 was 51.4 ± 16.4%, compared with 39.8 ± 15.4% in those who received aspirin and clopidogrel alone ...

Dr. Sabatine: Clopidogrel is a prodrug and it needs to be activated through sequential oxidative steps in the liver (Slide 1). There is another pathway where esterases can take that pro-drug and ...